For decades, scientists blamed the Krebs cycle and fat-burning machinery for making mitochondria leak toxic peroxide. But under moderate beta-oxidation, the usual suspects are exonerated. The real mystery is not why the cell is burning fuel—it’s what else inside the mitochondrion is making the dangerous exhaust.
Parkinson's disease and obstructive sleep apnea are locked in a devastating feedback loop, where each condition exacerbates the other through shared molecular pathways, creating a complex clinical challenge that current, siloed treatments fail to address.
Desulfovibrio is the kind of microbe most people have never heard of, yet it showed up more often and in higher amounts in the sickest among Parkinson’s patients. The temptation is obvious: if a suspicious bacterium tracks disease severity, maybe it helps cause the disease.